Endocrine Abstracts

Introduction: Normal or elevated TSH level in the presence of elevated T4 is defined as ‘inappropriate TSH syndrome’. Two main clinical conditions that can lead that syndrome are TSH-secreting adenoma (TSHoma) and resistance to thyroid hormone (RTH). Making the correct diagnosis is crucial in order to decide the most appropriate treatment option. Herein we presented clinical and laboratory data of seven patients who were hospitalised for the differential d...

Case: A 30-year-old man with hypoparathyroidism has been treated with calcitriol and calcium for 2 years, admitted hospital with persisting diarrhea. An endoscopic operation is planned. But when he was waiting for this examination as outpatient condition, he had a convulsion and had been taken in hospital by parents. Initial laboratory analyses revealed that he was hypocalcemic (total calcium of 6 mg/dl) and parathormone (PTH) 8 pg/ml, phosphorus 5.7 mg/dl, and magnesium 2 mg/...

Introduction: Major factor that modulates the PTH secretion is serum Ca level. Paratyhyroid gland also receives direct autonomic innervation. To date, measurement of several hormones such as cortisol,prolactin, renin and aldosteron were found to be affected by changing the posture from recumbent to the upright position. In the present study, we aimed to investigate postural change of PTH in normal individuals and patients with primary hyperparathyroidism (PHPT).<p class="a...

Introduction: Adrenal failure due to tuberculosis is rarely seen nowadays. There are few reports in the literature suggesting that adrenal insufficiency may improve with anti-tuberculosis therapy during the active phase of the disease. Herein, we presented a case of reversible adrenal failure in a patient with active tuberculosis.Case report: A 50-years-old-female patient admitted to our clinics with the complaints of weakness and darkening of the skin. ...

Introduction: Viruses and virus-induced lymphokines may have an important role in the pathogenesis of autoimmunity. The occurrence and significance of autoimmune manifestations after the administration of viral vaccines remain controversial. Herein we have represented a case who developed type 1 diabetes 1 month after vaccination for measles in military.Case: A 25-year-old male patient admitted to our clinics with the complaints of polyuria, poydipsia, a...

Introduction: Hypoglycemia is common in people with diabetes who aim to achieve strict glucose control. The neurologic manifestations of hypoglycemia are mostly reversible and includes behavioral changes, difficulty in concentration, confusion, loss of fine motor functions, and seizures. Herein we have presented a case who was pregnant and experienced severe hypoglycemia which led to permanent ataxia.Case: A 26-years-old female patient was brought to our...

Macroprolactinemia is reportedly 10–25% in patients with hyperprolactinemia (1). Prolactin plays a major role in breast development (2). Macromastia, gigantomastia, breast hypertrophy are used interchangeably (3). Most authors conclude that gigantomastia cannot be treated medically and only resolves with surgical manoeuvres (4). We report a case with gigantomastia diagnosed with macroprolactinemia and treated with cabergolin.Case: A 44-year-old woma...

Background: Prolactin secreting pituitary adenomas (prolactinomas) is the most common pituitary adenoma. The magnitude of prolactin secretion in prolactinomas is usually proportionate to the tumor’s size. Invasive giant prolactinoma is a large prolactinoma (>4 cm in dimension) presenting with serum prolactin levels of >1000 ng/ml and mass related clinical symptoms. Giant prolactinoma is rare and usually presents in men.Case report: A 52-year...

Case: A 63-year-old acromegalic woman admitted hospital for lassitude and dizziness. She has been diagnosed acromegaly 10 years ago and had two transsphenoidal operations. Remission wasn’t achieved. Then she started to use lanreotide (somatostatin analogue) and for 7 years she has been treated with it. In laboratory examination, basal plasma GH 1.21 ng/ml (NR:0–5); nadir GH level after glucose tolerance test, 1.2 ng/ml (NR: less than 1); IGF1, 129.1 ng/ml (NR: for ag...

Introduction: Ectopic thyroid tissue is the result of abnormal gland migration from the foramen caecum to its normal pretracheal position. An ectopic thyroid can be lingual (at the base of the tongue), sub-lingual (below the tongue), prelaryngeal (in front of the larynx), or can be found at other rare sites. The most frequent noncervical location for ectopic thyroid tissue is the thoracic cavity. Here we discuss about a rare case of mediastinal ectopic thyroid tissue presentin...